Meeting Schedule
Sunday, 5 October
13:00-14:00
Lunch
13:00-14:45
Registration
14:45-15:15
Coffee break
15:15-15:30
Welcome and introduction: Barbara van Loon, Magnus Steigedal (Norwegian University of Science and Technology, NO)
15:30-15:40
Introduction – video address by Vilhelm Bohr
15:40-19:10
Session 1. Physiological consequences of endogenous DNA damage
15:40-15:50
Discussion leader: Barbara van Loon
15:50-16:15
Bennett van Houten (University of Pittsburgh, USA), Watching base excision repair one molecule at a time: seeing is believing
16:15-16:30
Bente Benedict (Biotech Research & Innovation Centre (BRIC), University of Copenhagen, DK), Replication-coupled repair of formaldehyde-induced DNA histone lesions
16:30-16:55
Cathrine B. Vågbø (Norwegian University of Science and Technology, NO), Nucleobase damage quantification: pitfalls – and how to avoid them
16:55-17:10
Randi Syljuåsen (Oslo University Hospital), Transcription termination counteracts DNA damage after WEE1 inhibition
17:10-17:25
Break
17:25-17:50
Keith Caldecott (University of Sussex, UK), PARP activity in DNA replication, repair, and human disease
17:50-18:05
Lobke Mombeek (Hasselt University, BE), LIG3 mutation sensitizes CIPO patient fibroblasts to DNA damage and alters metabolic profiles
18:05-18:30
Deborah Caswell (University College London, UK), Mechanisms of APOBEC3B driven DNA damage in targeted cancer therapy resistance
18:30-18:45
Ingrun Alseth (Oslo University Hospital, Rikshospitalet, NO), ADA2 is a lysosomal deoxyadenosine deaminase acting on DNA regulating Toll-like receptor 9-mediated immune sensing of DNA
18:45-19:10
Agnel Sfeir (Sloan Kettering Institute, USA), Two Genomes, One Balance: Mitochondrial and Nuclear DNA Stability
20:00
Dinner
Monday, 6 October
8:45-9:40
Keynote address
8:45-8:50
Introduction – Barbara van Loon
8:50-9:40
Susan Gasser (Foundation ISREC, CH), TORC2 inhibition and nuclear actin drive chromosome fragmentation by interfering with base excision repair
9:40-12:45
Session 2. Endogenous DNA damage in accelerated ageing
9:40-9:50
Discussion leader: David M. Wilson III
9:50-10:15
Mariarosaria De Rosa (Opresko Lab) (University of Pittsburgh, USA), Oxidative DNA damage and repair at telomeres
10:15-10:45
Coffee break
10:45-11:10
Björn Schumacher (University of Cologne, DE), Genome Stability in Aging and Disease: New Insights from C. elegans
11:10-11:25
Nicola Montaldo (University of Oslo, NO), Mitochondrial DNA Repair: A Key to Preventing Brain Battery Failure in Parkinson's Disease
11:25-11:40
Katja Scheffler (Trondheim University Hospital and NTNU, NO), From Bench to Bedside: Targeting DNA glycosylase OGG1 in Alzheimer’s disease
11:40-12:05
Tinna V. Stevnsner (Aarhus University, DK), The role of aging and BDNF signaling in expression of base excision repair genes in the human brain
12:05-12:20
Diana Bordin (Akershus University Hospital and University of Oslo, NO), SMUG1 DNA glycosylase modulates reward behaviour through regulation of olfactory receptor gene expression
12:20-12:45
EMBO Young Investigator Lecture – Martijn Luijsterburg (Leiden University Medical Center, NL), CFAP20 salvages arrested RNAPII from the path of co-directional replisomes
13:00-14:00
Lunch
14:10-17:05
Session 3. Coordination of DNA repair
14:10
Discussion leader: Barbara van Loon
14:10-14:35
Amy Whitaker (Fox Chase Cancer Center, USA), Regulation of cancer-associated genes via DNA damage and repair
14:35-15:00
Anna Campalans (François Jacob Institute of Biology, FR), Repair of oxidative DNA damage in the chromatin context
15:00-15:15
Hervé Menoni (IAB-CNRS-UMR5309, FR), Decoding repair of oxidative DNA lesions via analysis of XRCC1 and PARP1 modalities of recruitment with live cell imaging
15:15-15:45
Coffee break
15:45-16:10
Sheila S. David (University of California, Davis, USA), Mysteries of MUTYH glycosylase: Mechanism, metal cofactors and MAP
16:10-16:25
Bodil Kavli (NTNU, NO), UNG in antibody class switching and uracil repair – How to be in the right place at the right time
16:25-16:50
Primo Schär (University of Basel, CH), Active DNA Demethylation Talking to RNA Polymerase?
16:50-17:05
Sarah Delaney (Brown University, USA), Interplay Between DNA Base Modifications, Repair Enzymes, and Chromatin Architecture
17:05-17:40
Poster pitches – Session 1
17:45-19:15
Poster session 1 – odd numbers
20:00
Dinner
Tuesday, 7 October
8:30-11:20
Session 4. Enabling Technologies
8:30-8:40
Discussion leader: Bevin P. Engelward
8:40-9:05
Alberto Ciccia (Columbia University, USA), Dissecting the genetic interaction network of the DNA damage response
9:05-9:20
Yun-Chung Hsiao (National Institute of Environmental Health Sciences (NIEHS/NIH), USA), Confluence of motif and signature analyses reveals mechanisms and key factors of mutagenesis in human cancer
9:20-9:45
Zachary D. Nagel (Harvard T.H. Chan School of Public Health, USA), Functional assays reveal new players in the repeat instability game
9:45-10:15
Coffee break
10:15-10:40
John Tainer (University of Texas MD Anderson Cancer Center, USA), SH2 and XRCC1 Adaptors in early DNA Repair Coordination
10:40-10:55
Federico Teloni (IMBA - Institut für Molekulare Biotechnologie GmbH, Austria), Cohesin guides homology search during DNA repair via loops and sister chromatid linkeages
10:55-11:20
Vakil Takhaveev (ETH, CH), Click-code-seq reveals how transcription, epigenetics, and aging shape DNA damage in the human genome
11:30-12:30
Lunch
13:35-14:30
Keynote address
13:35-13:40
Introduction – Bevin Engelward
13:40-14:30
Chuan He (University of Chicago, USA), Mammalian UV damage sensing and response
14:30-15:00
Coffee and refreshments
15:00-17:50
Session 5. Crosstalk between Endogenous DNA Damage and RNA Regulation
15:00-15:10
Discussion leader: Hilde L. Nilsen
15:10-15:35
Karlene Cimprich (Stanford University School of Medicine, USA), Mechanisms for RNA-Mediated Genome Instability
15:35-15:50
Alain Nepveu (McGill University, Canada), The Function of MYC in Base Excision Repair Protects against Oxidative DNA Damage and RAS-Induced Senescence
15:50-16:15
Gianluca Tell (University of Udine, IT), Emerging roles of bases modifications and DNA repair proteins in onco-miR processing: novel insights in cancer biology
16:15-16:30
Break
16:30-16:55
Arne Klungland (Oslo University Hospital, NO), Epitranscriptomic regulation and genome stability in meiosis
16:55-17:10
Marianne Farnebo (Karolinska Institute, SE), Dysregulation of the DNA Damage Response by Phosphorothioate Antisense Oligonucleotides
17:10-17:35
Nima Mosammaparast (Washington University, USA), Human MutLα activates methylpurine glycosylase to induce alkylation damage cytotoxicity
17:35-17:50
Ruben Harris (HHMI and UT Health San Antonio), Tobacco smoke carcinogens and other bulky DNA adducting agents exacerbate APOBEC mutagenesis and carcinogenesis
17:50-18:30
Poster pitches – Session 2
18:30-20:00
Poster session 2 – even numbers
20:00
Dinner
Wednesday, 8 October
9:00-12:30
Session 6. Clinical Potential of Endogenous DNA Damage Targeting
9:00-9:10
Discussion leader: Robert W. Sobol
9:10-9:35
Daniel Durocher (University of Toronto, CA), An endogenous source of DNA double-strand breaks for the non-homologous end-joining system
9:35-9:50
Maurice Michel (Karolinska Institute, SE), Chemical switching of OGG1 – rewiring base excision repair
9:50-10:05
Alessandro Sartori (University of Zurich, CH), Disruption of protein-protein interaction hot-spots in the C-terminal domain of MLH1 confers mismatch repair deficiency
10:05-10:45
Coffee break
10:45-11:10
Mark Kelley (Indiana University School of Medicine, USA), Targeting the DNA BER APE1/Ref-1 for cancer and other disease treatments
11:10-11:35
Marit Otterlei (Norwegian University of Science and Technology, NO), Novel roles of PCNA in cellular stress regulation
11:35-11:50
Sven Rottenberg (University of Bern, CH), Loss of mitochondrial ECHDC2 expression reduces oxidative damage of nuclear DNA and causes radiotherapy resistance
11:50-12:15
Michael B. Yaffe (Massachusetts Institute of Technology, USA), Protein Kinase Signaling and DNA Repair Choice in Cancer and Neurodegenerative Diseases
12:15-12:30
Guy Poirier (Laval University, CA), Emerging roles of Zinc Finger PAR-Interacting Proteins (ZIPPs) in DSB repair: implications in PARPi therapy
13:00-14:00
Lunch
14:00-17:40
Session 7. At the Intersection of DNA Repair Pathways
14:00-14:10
Discussion leader: Orlando D. Schärer
14:10-14:35
Joann Sweasy (University of Nebraska Medical Centre, USA), Genetic Variants in DNA Repair and Human Disease
14:35-14:50
Ingrid Tessmer (University of Wuerzburg, DE), Mechanistic insights into DNA alkylation damage repair at the single molecule level
14:50-15:05
Matt Schaich (University of Pittsburgh, USA), Nucleosome unwrapping and PARP1 allostery drive affinities for chromatin and DNA breaks
15:05-15:35
Coffee break
15:35-16:00
Bruce Demple (Stony Brook University, USA), The Long and the Short of Base Excision Repair in Human Cells and Xenopus Extracts
16:00-16:15
Robert Fuchs (bioHalosis, FR), Accidental encounter of DNA repair intermediates may lead to double-strand breaks in the absence of replication
16:15-16:30
Michael Lisby (University of Copenhagen, DE), ZGRF1 is a RAD51 interactor and facilitator in DNA repair
16:30-16:55
Puck Knipscheer (Hubrecht Institute, NL), Mechanism of BRCA2 activation for RAD51 recombinase assembly
16:55-17:10
Meng Wang (Cornell University, USA), Folate deficiency elevates endogenous genotoxic formaldehyde
17:10-17:25
David Häckes (Erasmus MC, NL), Repair Deficient TFIIH Causes Severe Disease Features via Persistent DNA Incisions
17:25-17:40
Vincent Pagès (CNRS, FR), Exonuclease activity modulates lesion bypass
17:40-18:00
Concluding remarks
19:00
Gala dinner
Thursday, 9 October
Breakfast on your own & departure