Meeting Schedule
Sunday, 5 October
11:30-13:30
Registration
10:30-12:30
Sightseeing (for participants arriving early)
13:00-14:00
Lunch
14:00
Welcome and introduction: Barbara van Loon (Norwegian University of Science and Technology, NO) and Bevin P. Engelward (Massachusetts Institute of Technology, USA)
14:10-15:10
Keynote Address
14:10-14:20
Introduction – address by Vilhelm Bohr
14:20-15:10
Chuan He (University of Chicago, USA), Reexamine UV damage repair
15:10-15:40
Coffee break
15:40-19:10
Physiological consequences of endogenous DNA damage
15:40-15:50
Discussion leader: Barbara van Loon
15:50-16:15
Joann Sweasy (University of Nebraska Medical Centre, USA), Genetic Variants in DNA Repair and Human Disease
16:15-16:30
Marina Bellani (NIA, NIH, USA), Endogenous aldehyde induced Replication stress during B cell activation
16:30-16:55
Peter J. McKinnon (St. Jude Children’s Hospital, USA), The impact of endogenous topoisomerase DNA damage
16:55-17:10
Bente Benedict (Biotech Research & Innovation Centre (BRIC), University of Copenhagen, DK), Replication-coupled repair of formaldehyde-induced DNA histone lesions
17:10-17:25
Break
17:25-17:50
Keith Caldecott (University of Sussex, UK), ADP-ribosylation in DNA strand break repair and DNA replication
17:50-18:05
Lobke Mombeek (Hasselt University, BE), LIG3 mutation sensitizes CIPO patient fibroblasts to DNA damage and alters metabolic profiles
18:05-18:30
Deborah Caswell (Francis Crick Institute, UK), The role of APOBEC3B in lung adenocarcinoma tumor progression and targeted therapy resistance
18:30-18:45
Ruben Harris (HHMI and UT Health San Antonio), Tobacco smoke carcinogens and other bulky DNA adducting agents exacerbate APOBEC mutagenesis and carcinogenesis
18:45-19:10
Agnel Sfeir (Sloan Kettering Institute, USA), Two Genomes, One Balance: Mitochondrial and Nuclear DNA Stability
20:00
Dinner
Monday, 6 October
8:45-9:40
Keynote address
8:45-8:50
Introduction – Barbara van Loon
8:50-9:40
Susan Gasser (Foundation ISREC, CH), Chromatin remodeling in DNA repair: too much, too little, just right
9:40-12:45
Endogenous DNA damage in accelerated ageing
9:40-9:50
Discussion leader: David M. Wilson III
9:50-10:15
Patricia L. Opresko (University of Pittsburgh, USA), Oxidative DNA damage and repair at telomeres
10:15-10:45
Coffee break
10:45-11:10
Björn Schumacher (University of Cologne, DE), Genome Stability in Aging and Disease: New Insights from C. elegans
11:10-11:25
Nicola Montaldo (University of Oslo, NO), Mitochondrial DNA Repair: A Key to Preventing Brain Battery Failure in Parkinson's Disease
11:25-11:40
Katja Scheffler (Trondheim University Hospital and NTNU, NO), From Bench to Bedside: Targeting DNA glycosylase OGG1 in Alzheimer’s disease
11:40-12:05
Tinna V. Stevnsner (Aarhus University, DK), The role of aging and BDNF signaling in expression of base excision repair genes in the human brain
12:05-12:20
David Häckes (Erasmus MC, NL), Repair Deficient TFIIH Causes Severe Disease Features via Persistent DNA Incisions
12:20-12:45
EMBO Young Investigator Lecture – Martijn Luijsterburg (Leiden University Medical Center, NL), Molecular mechanisms in transcription-coupled DNA repair
13:00-14:00
Lunch
14:00-17:05
Coordination of DNA repair
14:00-14:10
Discussion leader: Magnar Bjørås
14:10-14:35
Amy Whitaker (Fox Chase Cancer Center, USA), Regulation of cancer-associated genes via DNA damage and repair
14:35-15:00
Anna Campalans (François Jacob Institute of Biology, FR), Repair of oxidative DNA damage in the chromatin context
15:00-15:15
Hervé Menoni (François Jacob Institute of biology, FR), Decoding repair of oxidative DNA lesions via analysis of XRCC1 and PARP1 modalities of recruitment with live cell imaging
15:15-15:45
Coffee break
15:45-16:10
Sheila S. David (University of California, Davis, USA), Mysteries of MUTYH glycosylase: Mechanism, metal cofactors and MAP
16:10-16:25
Bodil Kavli (NTNU, NO), UNG in antibody class switching and uracil repair – How to be in the right place at the right time
16:25-16:50
Primo Schär (University of Basel, CH), TBA
16:50-17:05
Sarah Delaney (Brown University, USA), Interplay Between DNA Base Modifications, Repair Enzymes, and Chromatin Architecture
17:05-17:40
Poster pitches – Session 1
17:45-19:15
Poster session 1
20:00
Dinner
Tuesday, 7 October
8:30-11:20
Enabling Technologies
8:30-8:40
Discussion leader: Bevin P. Engelward
8:40-9:05
Alberto Ciccia (Columbia University, USA), CRISPR-based approaches to study the DNA damage response
9:05-9:20
Yun-Chung Hsiao (National Institute of Environmental Health Sciences (NIEHS/NIH), USA), Confluence of motif and signature analyses reveals mechanisms and key factors of mutagenesis in human cancer
9:20-9:45
Zachary D. Nagel (Harvard T.H. Chan School of Public Health, USA), Functional assays reveal new players in the repeat instability game
9:45-10:15
Coffee break
10:15-10:40
Cathrine B. Vågbø (Norwegian University of Science and Technology, NO), Nucleobase damage quantification: pitfalls – and how to avoid them
10:40-10:55
Federico Teloni (IMBA - Institut für Molekulare Biotechnologie GmbH, Austria), Cohesin guides homology search during DNA repair via loops and sister chromatid linkeages
10:55-11:20
Vakil Takhaveev (ETH, CH), Click-code-seq reveals how transcription, epigenetics, and aging shape DNA damage in the human genome
11:30-12:30
Lunch
12:45-14:45
Group activity
14:45-15:00
Coffee and refreshments
15:00-17:50
Crosstalk between Endogenous DNA Damage and RNA Regulation
15:00-15:10
Discussion leader: Hilde L. Nilsen
15:10-15:35
Karlene Cimprich (Stanford University School of Medicine, USA), The Causes and Consequences of Replication Stress
15:35-15:50
Alain Nepveu (McGill University, Canada), The Function of MYC in Base Excision Repair Protects against Oxidative DNA Damage and RAS-Induced Senescence
15:50-16:15
Gianluca Tell (University of Udine, IT), Emerging roles of bases modifications and DNA repair proteins in onco-miR processing: novel insights in cancer biology
16:15-16:30
Break
16:30-16:55
Arne Klungland (Oslo University Hospital, NO), Epitranscriptomic regulation and genome stability in meiosis
16:55-17:10
Marianne Farnebo (Karolinska Institute, SE), Dysregulation of the DNA Damage Response by Phosphorothioate Antisense Oligonucleotides
17:10-17:35
Nima Mosammaparast (Washington University, USA), RNA Damage: The canary in the coal mine?
17:35-17:50
Ingrun Alseth (Oslo University Hospital, Rikshospitalet, NO), ADA2 is a lysosomal deoxyadenosine deaminase acting on DNA regulating Toll-like receptor 9-mediated immune sensing of DNA
17:50-18:30
Poster pitches – Session 2
18:30-20:00
Poster session 2
20:00
Dinner
Wednesday, 8 October
9:00-12:30
Clinical Potential of Endogenous DNA Damage Targeting
9:00-9:10
Discussion leader: Robert W. Sobol
9:10-9:35
Daniel Durocher (University of Toronto, CA), Synthetic lethality as a tool to uncover sources of endogenous DNA damage
9:35-9:50
Maurice Michel (Karolinska Institute, SE), Chemical switching of OGG1 – rewiring base excision repair
9:50-10:05
Alessandro Sartori (University of Zurich, CH), Disruption of protein-protein interaction hot-spots in the C-terminal domain of MLH1 confers mismatch repair deficiency
10:05-10:45
Coffee break
10:45-11:10
Mark Kelley (Indiana University School of Medicine, USA), Targeting the DNA BER APE1/Ref-1 for cancer and other disease treatments
11:10-11:35
Marit Otterlei (Norwegian University of Science and Technology, NO), Novel roles of PCNA in cellular stress regulation
11:35-11:50
Sven Rottenberg (University of Bern, CH), Loss of mitochondrial ECHDC2 expression reduces oxidative damage of nuclear DNA and causes radiotherapy resistance
11:50-12:15
Mike Yaffe (Massachusetts Institute of Technology, USA), A Multi-Pathway DNA Repair Reporter Reveals Competition, Compensation, and Unexpected Complexity at Single Genomic Double Strand Breaks
12:15-12:30
Guy Poirier (Laval University, CA), Emerging roles of Zinc Finger PAR-Interacting Proteins (ZIPPs) in DSB repair: implications in PARPi therapy
13:00-14:00
Lunch
14:00-17:40
At the Intersection of DNA Repair Pathways
14:00-14:10
Discussion leader: Orlando D. Schärer
14:10-14:35
Ben van Houten (University of Pittsburgh, USA), Watching base excision repair one molecule at a time: seeing is believing
14:35-14:50
Ingrid Tessmer (University of Wuerzburg, DE), Mechanistic insights into DNA alkylation damage repair at the single molecule level
14:50-15:05
Matt Schaich (University of Pittsburgh, USA), Nucleosome unwrapping and PARP1 allostery drive affinities for chromatin and DNA breaks
15:05-15:35
Coffee break
15:35-15:50
John Tainer (University of Texas MD Anderson Cancer Center, USA), SH2 and XRCC1 Adaptors in early DNA Repair Coordination
15:50-16:15
Bruce Demple (Stony Brook University, USA), The Long and the Short of Base Excision Repair in Human Cells and Xenopus Extracts
16:15-16:30
Robert Fuchs (bioHalosis, FR), Accidental encounter of DNA repair intermediates may lead to Double-Strand Breaks in the absence of replication
16:30-16:45
Michael Lisby (University of Copenhagen, DE), ZGRF1 is a RAD51 interactor and facilitator in DNA repair
16:45-17:10
Puck Knipscheer (Hubrecht Institute, NL), Repair mechanism of aldehyde-induced DNA interstrand crosslinks
17:10-17:25
Meng Wang (Cornell Univerity, USA), Folate deficiency elevates endogenous genotoxic formaldehyde
17:25-17:40
Vincent Pagès (CNRS, FR), Exonuclease activity modulates lesion bypass
17:40-18:00
Concluding remarks & poster awards
19:00
Gala dinner
Thursday, 9 October
Breakfast on your own & departure