Static Schedule
7th US-EU Meeting
Program Summary
NOTE: All sessions take place in the Wang Center
Sunday, 6 November
6:00 PM Welcome and introduction: Bruce Demple and Vilhelm Bohr
6:15 PM Keynote Address
Joann Sweasy (University of Arizona) DNA repair and autoimmunity
7:00 PM Reception
Monday, 7 November
8:00-9:00 AM Breakfast at the Wang Center
9:00 AM-12:30 PM Cancer Etiology
9:00-9:10 Discussion leader: Robert Sobol
9:10-9:35 Kara Bernstein (University of Pennsylvania)
RAD51 paralog function in DNA damage tolerance and cancer
9:35-10:00 Gianluca Tell (University of Udine, Italy)
Understanding non-canonical functions of APE1 from the study of its RNA- and
protein-interactomes
10:00-10:15 Short Talk 1
10:15-10:45 Coffee Break
10:45-11:10 Stephen Cappell (NCI, Bethesda, MD) Predicting cell fates outcomes in response to DNA damage
11:10-11:35 K.J. Patel (MRC, Oxford, UK)
Simple aldehydes – a preventable common source of endogenous DNA damage and mutations?
11:35-12:00 Bevin Engelward (MIT, Cambridge, MA) The consequences of methylation damage to DNA
12:00-12:15 Short Talk 2
12:15-12:30 Short Talk 3
12:30-1:30 Lunch On Your Own
1:30-5:00 PM Replication forks: problems and solutions
1:30-1:40 Discussion Leader: Alessandro Vindigni
1:40-2:05 David Cortez (Vanderbilt University, Nashville, TN)
Regulation of replication-coupled DNA repair and tolerance mechanisms
2:05-2:30 Hyungjin Kim (Stony Brook University, NY)
Roles of TIMELESS in DNA replication fork integrity and cancer therapy
2:30-2:55 F. d’Adda di Fagagna (IFOM, Milan, Italy) Telomere DNA damage in human diseases
2:55-3:20 Coffee Break
3:20-3:45 Roger Greenberg (University of Pennsylvania)
A new AAA ATPase complex in replication protein quality control
3:45-4:10 Karlene Cimprich (Stanford University, CA) RNA Meets DNA: Dangerous Liaisons in the Genome
4:10-4:25 Short Talk 1
4:25-4:40 Short Talk 2
4:40-4:55 Short Talk 3
5:00-7:00 PM Poster Session & Refreshments
Tuesday, 8 November
8:00-9:00 AM Breakfast at the Wang Center
9:00-12:30 AM Aging and Epigenetics
9:00-9:10 Discussion Leader: Hilde Nilsen
9:10-9:35 Cynthia Burrows (University of Utah)
BER-mediated epigenetic regulation by oxidative stress in promoter G-quadruplexes
9:35-10:00 Patty Opresko (University of Pittsburgh) Oxidative DNA damage and repair at telomeres
10:00-10:15 Short Talk 1
10:15-10:45 Coffee Break
10:45-11:10 Karen Usdin (NIH, Bethesda, MD)
The dark side of DNA repair in the etiology of the repeat expansion diseases
11:10-11:35 Primo Schär (University of Basel, Switzerland)
DNA base excision repair, dynamic DNA methylation and
the control of endogenous retroviral elements
11:35-12:00 Vera Gorbunova (University of Rochester, NY) Genome stability and aging
12:00-12:15 Short Talk 2
12:15-12:30 Short Talk 3
12:30-2:30 Poster Session & Refreshments
From 2:30 PM Free Afternoon & Evening
Wednesday, 9 November
8:00-9:00 AM Breakfast at the Wang Center
9:00-12:30 AM DNA Repair in Transcription and Disease
9:00-9:10 Discussion Leader: Bret Freudenthal
9:10-9:35 Barbara van Loon (NTNU, Trondheim, Norway)
Crosstalk between base excision repair and gene expression
9:35-10:00 Johannes Walter (Harvard Med. School, Boston)
Transcription-coupled DNA repair in a test tube
10:00-10:15 Short Talk 1
10:15-10:45 Coffee Break
10:45-11:10 Nina Papavasiliou (DKFC, Heidelberg, Germany)
Consequences of collateral DNA damage due to "off target" RNA editing
11:10-11:35 Nima Mosammaparast (Washington University, St. Louis) How RNA processing links to DNA repair
11:35-12:00 Keith Caldecott, University of Sussex, UK
Sources of endogenous DNA single-stand breakage and
associated pathology, in human genetic disease
12:00-12:15 Short Talk 2
12:15-12:30 Short Talk 3
12:30-1:30 Lunch On Your Own
1:30-4:05 PM New Pathways in Cancer Treatment
1:30-1:40 Discussion Leader: David Wilson: Introduction
1:40-2:05 Reuben Harris (HHMI and the University of Texas, San Antonio)
DNA deaminase-catalyzed mutation in human disease
2:05-2:30 Jean-Yves Masson (Laval University, Quebec, Canada)
PALB2: from molecular functions to the effect of PARP inhibitors on specific missense mutations
2:55-3:20 Coffee Break
3:20-3:45 Diana L. Bordin (Åkershus University Hospital, Oslo, Norway)
A national precision cancer medicine implementation initiative for Norway
3:45-4:10 Susan Rosenberg (Baylor College of Medicine, Texas) The DNA Damageome and Cancer
4:10-4:25 Short Talk 1
Capstone Talk
4:30-4:35 Introduction: Roger Woodgate
4:35-5:25 Maria Jasin (Memorial Sloan-Kettering Cancer Center, New York)
Homologous recombination as a safeguard against tumorigenesis
5:25-5:45 Tomas Lindahl (Cancer Research UK, London)
Q&A Session
6:00-9:00 PM Conference banquet at the Wang Center
Thursday, 10 November
Breakfast on your own & departure